Judith Hofmann was born in Zurich. She studied at the Max Reinhardt Seminar in Vienna and from 1994 to 1999 was engaged at the Staatstheater in Munich, from 1999 to 2001 at the Burgtheater in Vienna and from 2001 to 2009 at the Thalia Theater in Hamburg. In 2006 she was nominated for the Nestroy for her role as Beatrice in Much Ado About Nothing (director: David Bösch). Since the 2009/10 season she has been a member of the Deutsches Theater ensemble, where she appeared in productions by Andreas Kriegenburg, Stephan Kimmig, Alize Zandwijk, Jette Steckel, Rafael Sanchez, René Pollesch, Anne Lenk, Tom Kühnel and Jürgen Kuttner. In 2010 she was awarded the Tilla-Durieux-Schmuck, which spends ten years in the possession of an "outstanding German actor". In 2019 she won the Swiss Film Award as best actress for the role of Ruth in Simon Jaquemets movie Der Unschuldige (The Innocent). Currently she can be seen in Dear Yelena Sergeyewna, (Life on earth can be sweet) Donna, The Giraffe's Neck, The Misanthrope, Revolutionary Road, Cry Baby, Ulysses, The Chips are Down and Thieves.