Friederike Drews studied acting in Berlin from 2008 to 2012. After working in the independent theatre scene, she completed a traineeship at Künstlerhaus Lukas e.V. Ahrenshoop in 2014 and was hired as an actress at the Volkstheater Rostock ( artistic director Sewan Latchinian). Here she worked with directors such as Sewan Latchinian, Martin Stefke, Jürgen Eick, Angelika Zacek and Beatrix Schwarzbach. In 2016, she staged ‘Spieltrieb’ here with the student youth club Sometimes love ruled and sometimes simply nobody by Laura Naumann.

From 2019 until the end of Ulrich Khuon's artistic directorship, Friederike Drews worked as an assistant director at Deutsches Theater Berlin with Andres Veiel, Philipp Arnold, Anne Lenk, Andreas Kriegenburg, Jette Steckel, Armin Petras, Lilja Rupprecht, René Pollesch and Jossi Wieler, among others. In 2021, she developed a theatre one-take film with DT ensemble members Niklas Wetzel and Julia Windischbauer: Bremsspuren by Nicola Bremer was the Deutsches Theater's first digital limited edition. At the Gerhart Hauptmann Theatre in Görlitz-Zittau, she staged Der Kontrabass by Patrick Süsskind in 2022. Mein Leben in Aspik by Steven Uhly in a version by Friederike Drews premiered in the Box on 29 September 2022 and Anne-Marie die Schönheit by Yasmina Reza, also directed by Friederike Drews, will premiere in Room 315 of the Deutsches Theater on 1 April 2023. In addition to her practical theatre work, Friederike Drews has been studying Cultural and Media Management (Bachelor of Arts) at the University of Music and Theatre in Hamburg since 2019.