Following engagements at the Volksbühne am Rosa-Luxemburg-Platz Berlin, Schauspiel Frankfurt, Staatstheater Hannover, Staatstheater Kassel, Neue Bühne Senftenberg, Theater Magdeburg, Staatstheater Kassel, Schauspielhaus Zürich, Deutsches Schauspielhaus in Hamburg and Maxim Gorki Theater Berlin, Peter René Lüdicke was a permanent member of the ensemble at Centraltheater Leipzig from 2008 to 2013. He has worked with directors including Frank Castorf, Andreas Kriegenburg, Sebastian Hartmann, Leander Haußmann, Martin Laberenz, Sebastian Baumgarten, Robert Borgmann, Amina Gusner, Armin Petras, Luk Perceval and Claus Peymann.

From 2013 to 2018, Peter René Lüdicke was a permanent member of the Schauspiel Stuttgart ensemble. He has also worked in various film and television productions, including the cinema films Whatever happens next (2018) directed by Julian Pörksen and Das Mädchen mit den goldenen Händen (2022) directed by Katharina Marie Schubert.

Peter René Lüdicke has been a member of the ensemble at Deutsches Theater Berlin since the 2019/20 season.